Unica.it - Dipartimento di Biologia Sperimentale, Università degli Studi di Cagliari

Collaborazioni Nazionali dal 1998

PROF.SSA BARBACCIA MARIA LUISA
Dipartimento di Medicina Sperimentale,
Università degli Studi di Roma "Tor Vergata"
Via di Tor Vergata, 135 - 00133 ROMA

Concas A., Mostallino M.C., Porcu P., Barbaccia M.L., Trabucchi M., Purdy R.H., Grisenti P. and Biggio G.
Role of brain allopregnanolone in the plasticity of g -aminobutyric acid type A receptor in rat brain during pregnancy and after delivery.
Proc Nati. Acad. Sci. USA, 95: 13284-13289, 1998.

Barbaccia M.L., Concas A., Serra M. and Biggio G.
Stress and neurosteroids in adult and aged rats.
Experimental Gerontology 33: 697-712,1998

Concas A., Follesa P., Barbaccia M.L., Purdy R.H. and Biggio G.
Physiological modulation of GABA_A receptor plasticity by progesterone metabolites.
Eur. J. Pharmacol. 375: 225-235, 1999.

Barbaccia M.L. and Biggio G.
Basi biologiche della dipendenza da benzodiazepine.
In: Trattato Italiano di Psichiatria (Coordinatori: P. Pancheri and G. Cassano) Vol. III, pp. 3272-3278, 1999.

Serra M., Madau P., Chessa M.F., Caddeo M., Sanna E., Trapani G., Franco M., Liso G., Purdy R.H., Barbaccia M.L. and Biggio G.
2-phenyl-imidazo[1,2-a]pyridine derivatives as ligands for peripheral benzodiazepine receptors: stimulation of neurosteroid synthesis and anticonflict action in rats.
British J. Pharmacol. 127: 177-187, 1999.

Biggio G., Barbaccia M.L., Follesa P., Serra M., Purdy R.H. and Concas A.
Neurosteroids and GABA_A receptor plasticity. In: GABA in the nervous system. The view at fifty years"
(Eds. Olsen R.W. and Martin D.L.). Lippincott, pp. 207-232, 2000.

Barbaccia M.L., Serra M., Purdy R.H. and Biggio G.
Stress and neuroactive steroids.
In: Neurosteroids and Brain Function (Eds. Biggio G. and Purdy R.H.),
International Review of Neurobiology, Academic Press, Vol. 46, pp. 243-2
272, 2001.

Barbaccia M.L., Affricano D., Purdy R.H., Maciocco E.,
Spiga F.and Biggio G..
Clozapine, but not haloperidol, increases brain concentrations of neuroactive steroids in the rat.
Neuropsychopharmacol.,25: 489-497, 2001.

PROF.SSA BELLODI LAURA, PROF.SSA BRAMBILLA FRANCESCA
Centro di Psiconeuroendocrinologia. Clinica Psichiatrica, Ospedale S. Raffaele - 20129 Milano
Ricerca in corso: Ruolo dei neurosteroidi nella sensibilità alla inalazione di CO₂ inpazienti affetti da disturbo d'attacco di panico.

Brambilla F., Biggio G., Pisu M.G., Bogdanovich-Djikic V., Purdy R.H. and Serra M.
Neurosteroid secretion in panic disorder.
Psychiatry Research118: 107-116, 2003.

Brambilla F, Biggio G, Pisu MG, Purdy RH, Gerra G, Zaimovich A, Serra M.
Plasma concentrations of anxiolytic neurosteroids in men with normal anxiety scores: a correlation analysis.
Neuropsychobiology. 2004;50(1):6-9.

PROF. CAPPELLI ANDREA, PROF. ANZINI MAURIZIO
Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, via A. Moro, 53100 Siena.

Cappelli A., Mohr G.M., Gallelli A., Giuliani G., Anzini M., Vomero S., Fresta M., Porcu P., Maciocco E., Concas A., Biggio G. and Donati A.
Targeted delivery of radionuclides and boron atoms by means of peripheral benzodiazepine receptor ligands. Structure-activity relationship studies on carboxamide derivatives.
J. Med. Chem., in press

PROF. CAROTTI ANGELO
Dipartimento Farmaco Chimico, Università degli Studi di Bari, Via E. Orabona, 4 - 70125 Bari

PROF.SSA SAVINI LUISA
Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via Banchi di Sotto, 55 - Siena

Savini L., Massarelli P., Nencini C., Pellerano C., Biggio G., Maciocco E., Tuligi G., Carrieri A., Cinone N. and Carotti A.
High affinity central benzodiazepine receptor ligands: synthesis and stucture-activity relationship studies of a new series of pyrazolo[4,3-c]quinolin-3-ones.
Bioorganic & Med. Chemistry 6: 389-399, 1998.

Savini L., Chiasserini L., Pellerano C., Biggio G., Maciocco E., Serra M., Cinone N., Carrieri A., Altomare C. and Carotti A.
High affinity central benzodiazepine receptor ligands. Part 2: Quantitative structure-activity relationships and comparative molecular field analysis of pyrazolo[4,3-c]quinolin-3-ones.
Bioorganic &Medical Chemistry 9: 431-444, 2001.

PROF.SSA DEL FIACCO MARINA
Dipartimento di Citomorfologia, Università degli Studi di Cagliari, Cittadella Universitaria, Monserrato (Cagliari)

Del Fiacco M., Quartu M., Serra M.P., Follesa P., Lai M.L. and Bachis A.
Topographical localization of glial cell line-derived neurotrophic factor in the human brain stem: an immunohistochemical study of prenatal, neonatal and adult brains.
J. Chem. Neuroanat.23: 299-304, 2002.

Pina Serra M, Quartu M., Ambu R., Follesa P. and Del Fiacco M.
Immunohistochemical localization of GDNF in the human hippocampal formation from prenatal life to adulthood.
Brain Res. 928: 138-146, 2002.

Serra M.P., Quartu M., Lai M.L., Follesa P. and Del Fiacco M.
Expression of glial cell line-derived neurotrophic factor mRNA in the human newborn and adult hippocampal formation.
Brain Res. 928: 160-164, 2002.

Quartu M., Serra M.P., Manca A., Follesa P., Lai M.L. and Del Fiacco M.
Neurotrophin-like immunoreactivity in the human pre-term newborn, infant, and adult cerebellum.
Int. J.Dev. Neurosci 21: 23-33, 2003.

Quartu M., Serra M.P., Manca A., Follesa P., Ambu R. and Del Fiacco M.
High affinità neurotrophin receptors in the human pre-term newborn, infant, and adult cerebellum.
Int. J.Dev. Neurosci 21: 309-320, 2003.

PROF. GENAZZANI ANDREA
Istituto di Cllnica Ostetrica e Ginecologica, Università degli Studi di Pisa, Via Roma, 35 - 56100 Pisa.

PROF. PETRAGLIA FELICE
Cattedra di Ginecologia e Ostetricia, Università degli Studi di Udine, Pie S. Maria della Misericordia - 33100 Udine.

Serra M., Concas A., Mostallino M.C., Chessa M.F., Stonati M., Petraglia E, Genazzani A.R. and Biggio G.
Antagonism by pivagabina of stress-induced changes in GABA_A receptor function and corticotropin-releasing-factor concentrations in rat brain.
Psychoneuroendocrinology 24:269-284, 1999.

PROF. LISO GAETANO, PROF. TRAPANI GIUSEPPE
Dipartimento Farmaco Chimico,
Università degli Studi di Bari. Via E. Orabona, 4 - 70125 Bari

Trapani G., Latrofa A., Franco M., Altomare C., Sanna E., Usala M., Biggio G. and Liso G.
Propofol analogues. Synthesis, relationships between structure and affinity at GABA_A receptor in rat brain, and differential electrophysiological profile at recombinant human GABA_A receptors.
J. Med. Chem. 41: 1846-1854, 1998.

Trapani G., Latrofa A., Franco M., Lopedota A., Maciocco E. and Liso G.
Water-soluble salts ofaminoacid esters of the anaesthetic agent propofol.
International J. Pharmaceutics, 175: 195-204, 1998.

Sanna E., Motzo C., Usala M., Serra M., Dazzi L., Maciocco E., Trapani G., Latrofa A., Liso G. and Biggio G.
Characterization of the electrophysiological and pharmacological effects of 4-iodo-2,6-diisopropyl phenol, a propofol analogue devoid of sedative-anaesthetic properties.
British J. Pharmacol. 126: 1444-1454, 1999.

Serra M., Madau P., Chessa M.F., Caddeo M., Sanna E., Trapani G., Franco M., Liso G., Purdy R., Barbaccia M.L. and Biggio G.
2-Phenyl.imidazo[1,2-a]pyridine derivatives as ligands for peripheral benzodiazepine receptors: stimulation of neurostero id synthesis and anticonflict action in rats.
British J. Pharmacol. 127: 177-187, 1999.

Trapani G., Franco M., Latrofa A., Ricciardi L., Carotti A., Serra M., Sanna E., Biggio G., and Liso G.
Novel 2-Phenyl-imidazo[1,2-a]pyridine derivates as potent and selective ligands for peripheral benzodiazepine receptors. Synthesis, binding affinity, and in vivo studies.
J. Med. Chem.42: 3934-3941, 1999.

Trapani G., Franco M., Latrofa A., Pantaleo M.R., Provenzano M.R., Sanna E., Maciocco E. and Liso G.
Psychochemical characterization and in vivo properties of zolpidem in solid dispersion with polyethylene glycol 4000 and 6000.
Int. J. Pharmacol. 184: 121-130, 1999.

Trapani G., Altomare C., Sanna E., Biggio G. and Liso G.
Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery.
Current Med. Chem. 7: 249-271, 2000.

Trapani G., Latrofa A., Franco M., Pantaleo M.R., Sanna E., Massa F., Tuveri F. and Liso G.
Complexation of zolpidem with 2-hydroxypropyl-beta-,methyl-beta-,and 2-hydroxypropyl-gamma-cyclodextrin: effect on aqueous solubility, dissolution rate, and ataxic activity in rat.
Journal of Pharmaceutical Sciences 89: 1443-1451, 2000.

Latrofa A., Trapani G., Franco M., Harris M.J., Serra M., Biggio G. and Liso G.
Synthesis of the [³H] labeled potent and selective peripheral benzodiazepine receptor ligand CB 34.
J. Labelled Cpd Radiophar., 44: 521-528, 2001.

Franco M., Trapani G., Latrofa A.,Tullio C., Provenzano M.R., Serra M., Muggironi M., Biggio G. and Liso G.
Dissolution properties and anticonvulsant activity of phenytoin-polyethylene glycol 6000 and -polyvinylpyrrolidone K-30 solid dispersions.International J. Pharmaceutics 225: 63-73, 2001

Pisu M.G., Papi G., Porcu P., Trapani G., Latrofa A., Biggio G. and Serra M.
Binding of [³H]CB 34, a selective ligand for peripheral benzodiazepine receptors, to rat brain membranes.
Eur. J. Pharmacol., 432 : 129-134, 2001.

Latrofa A., Trapani G., Franco M., Serra M., Muggirono M., Fanizzi F.P., Cutrignelli A. and Liso G.
Complexation of phenytoin with some hydrophilic cyclodextrins: effect on aqueous solubilità, dissolution rate, and anticonvulsant activity in mice.
Eur. J. Pharm. and Biopharm. 52: 65-73, 2001.

Follesa P., Mancuso L., Biggio F., Cagetti E., Franco M., Trapani G. and Biggio G.
Changes in GABA_A receptor gene expression induced by withdrawal of, but not by long-term exposure to, zaleplon or zolpidem.
Neuropharmacol., 42: 191-198, 2002.

Dazzi L., Serra M., Vacca G., Ladu S., Latrofa A., Trapani G. and Biggio G..
Depletion of cortical allopregnanolone potentiates stress-induced increase in cortical dopamine output.
Brain Res., 932: 135-139, 2002

Trapani G., Dazzi L., Pisu M.G., Reho A., Seu E. and Biggio G.
A rapid method for obtaining finasteride, a 5α-reductase inhibitor, from commercial tablets.
Brain Res. Prot., 9(2): 130-134, 2002.

Asproni B., Pau A., Bitti M., Melosu M., Cerri R., Dazzi L., Seu E., Maciocco E., Sanna E., Busonero F., Talani G., Pusceddu L., Altomare C., Trapani G. and Biggio G.
Synthesis and pharmacological evaluation of 1-[1,2-diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with clozapine-like mixed activities at dopamine D₂ serotonin, and GABA_A receptors.
J. Med. Chem. 45: 4655-4668, 2002.

Trapani G., Latrofa A., Franco M., Carrieri A., Cellamare S., Serra M., Sanna E., Biggio G. and Liso G.
Alpidem analogues containing a GABA or glicine moiety as new anticonvulsant agents.
Eur. J. Pharm. Sci. 18: 231-240, 2003.

Trapani G, Cutrignelli A, Latrofa A, Franco M, Serra M, Pisu MG, Biggio G, Liso G.
Valproic acid-hydrophilic cyclodextrin complexes and valproic acid-solid dispersions: evaluation of their potential pharmaceutical use.
Drug Dev Ind Pharm. 2004 Jan;30(1):53-64.

PROF. MARROSU FRANCESCO
Dipartimento Scienze Neurologiche e Cardiovascolari Policlinico di Monserrato Cagliari, Blocco D Stanza 11 Cittadella Universitaria di Monserrato (Cagliari)

Marrosu F., Serra A., Malesi A., Puligheddu M., Biggio G. and Piga M.
Correlation between GABA_A receptor density and vagus nerve stimulation in individuals with drug-resistant partial epilepsy.
Epilepsy Res.55 59-70, 2003.

PROF. MELIS GIAN BENEDETTO,
PROF.SSA PAOLETTI ANNA MARIA
Dipartimento di Ostetricia e Ginecologia, Università di Cagliari, 09124 Cagliari

Paoletti A.M., Lello S., Fratta S., Orrù M., Ranuzzi F., Sogliano C., Concas A., Biggio G, and Melis G.B.
Psychological effect of the oral contraceptive formulation containing 3 mg drospirenone plus 30 mg ethinylestradiol: possibile relationship with decreased DHEAS levels.
Fertility and Sterility, 81:645-651, 2004.

PROF. MONTELEONE PALMIERO
Dipartimento di Psichiatria, Neuropsichiatria Infantile, Audiofoniatria e Dermatovenereologia, II Università degli Studi di Napoli, L.go Madonna delle Grazie, 2 - 80138 Napoli

Monteleone P., Serra M., Biggio G. and Maj M.
Long term treatment with clozapine does not affect circulating levels of allopregnanolone and THDOC in schizophrenic patients.
Clinical Psychopharmacology, 2004, in press.

PROF.SSA PIEROBON PAOLA
Istituto di Cibernetica CNR - Via Toiano, 6 -80072 Arco Felice, Napoli

Pierobon P., Concas A., Santoro G., Marino G., Minei R., Pannaccione A., Mostallino M.C. and Biggio G.
Biochemical and functional identification of GABA receptors in Hydra vulgaris.
Life Sciences, 56: 1485-1497, 1995.

Concas A., Pierobon P., Mostallino M.C., Marino G., Minei R. and Biggio G.
Modulation of "g-amino butyric, acid (GABA) receptors and the feeding response by neurosteroids in Hydra Vulgaris.
Neuroscience 85: 201-210, 1998.

Pierobon P., Minei R., Porcu P., Sogliano C., Tino A., Marino G., Biggio G.and Concas A.
Putative glycine receptors in Hydra: a Biochemical and behavioural study.Eur. J. Neurosc., 14 : 1659-1666, 2001.

PROF. TORTA RICCARDO
Dipartimento di Psichiatria, Università degli Studi di Torino. Via Cherasco, 11 - 10126 Torino

Torta R. and Biggio G.
Le benzodiazepine: basi biochimiche, farmacodinamica e farmacocinetica. In: Trattato Italiano di Psichiatria (Coordinatori: P. Cancheri e G. Cassano) Vol. III, pp. 3228-3244, 1999.

PROF MARCO SASSO E POGNETTO
Dipartimento di Anatomia Farmacologia, Medicina Legale, Università degli Studi di Torino, Corso Massimo D'Azeglio, 52 10126 Torino

PROF.SSA CAROLA EVA
Dipartimento di Anatomia Farmacologia, Medicina Legale, Università degli Studi di Torino, via Pietro Giuria 13, 10125 Torino

Ferrara G, Serra M, Zammaretti F, Pisu MG, Panzica GC, Biggio G, Eva C.
Increased expression of the neuropeptide Y receptor Y(1) gene in the medial amygdala of transgenic mice induced by long-term treatment with progesterone or allopregnanolone.
J Neurochem. 2001 Oct;79(2):417-25.

Oberto A, Serra M, Pisu MG, Biggio G, Eva C.
Changes in expression of the neuropeptide Y Y1 receptor gene in the medial amygdala of transgenic mice during pregnancy and after delivery.
J Neurochem. 2002 Sep;82(5):1272-81.

Mele P, Oberto A, Serra M, Pisu MG, Floris I, Biggio G, Eva C.
Increased expression of the gene for the Y1 receptor of neuropeptide Y in the amygdala and paraventricular nucleus of Y1R/LacZ transgenic mice in response to restraint stress.
J Neurochem. 2004 Jun;89(6):1471-8.