Coordinatore:
Prof. GIOVANNI BIGGIO (Professore Ordinario)
Esperienze in Laboratori esteri:
1973 Visiting Fellow "B. Baron Memorial Research Laboratory" Department of Chemical Pathology di Londra.
1974-1976 Visiting Associate "Laboratory Preclinical Pharmacology" NIMH, Washington D.C.
Linee di ricerca:
a) Studio dei meccanismi ormonali e neurochimici che controllano la sfera emozionale e affettiva.
b) Sviluppo di nuovi farmaci ansiolitici, anticonvulsivanti ed anestetici generali.
c) Sviluppo di nuove molecole stimolanti la sintesi di steroidi.
d) Studio delle variazioni strutturali e funzionali dei recettori GABAA dagli invertebrati al cervello dell'uomo. CINQUE LAVORI PIÙ SIGNIFICATIVI PUBBLICATI NEGLI ULTIMI 5 ANNI
Follesa P., Concas A., Porcu P., Sanna E., Serra M., Mostallino M.C., Purdy R.H., Biggio G.
Role of allopregnanolone in regulation of GABAA receptor plasticity during long-term exposure to and withdrawal from progesterone.
Brain Res. Reviews, Vol. 37, pp. 81-90, 2001.
Dazzi L., Serra M., Seu E., Cerchi G., Pisu M.G., Purdy R.H., Biggio G.
Progesterone enhances ethanol-induced modulation of mesocortical dopamine neurons: antagonism by finasteride.
J. Neurochem. 83: 1103-1109, 2002.
Biggio G, Dazzi L, Biggio F, Mancuso L, Talani G, Busonero F, Mostallino MC, Sanna E, Follesa P.
Molecular mechanisms of tolerance to and withdrawal of GABA(A) receptor modulators
Eur Neuropsychopharmacol. 2003 Dec;13(6):411-23. Mostallino MC, Mascia MP, Pisu MG, Busonero F, Talani G, Biggio G.
Inhibition by miltirone of up-regulation of GABAA receptor alpha4 subunit mRNA by ethanol withdrawal in hippocampal neurons.
Eur J Pharmacol. 2004 Jun 28;494(2-3):83-90. Sanna E, Talani G, Busonero F, Pisu MG, Purdy RH, Serra M, Biggio G.
Brain steroidogenesis mediates ethanol modulation of GABAA receptor activity in rat hippocampus.
J Neurosci. 2004 Jul 21;24(29):6521-30. EDITORE DEI SEGUENTI LIBRI
ADVANCES IN BIOCHEMICAL PSYCHOPHARMACOLOGY SERIES
Benzodiazepine Recognition Site Ligands: Biochemistry and Pharmacology.
In: Advances in Biochemical Psychopharmacology, Vol. 38, 1983 (Eds. Biggio G. and Costa E.), Raven Press, New York.
GABAergic Transmission and Anxiety.
In: Advances in Biochemical Psychopharmacology, Vol. 41, 1986 (Eds. Biggio G. and Costa E.), Raven Press, New York.
Chloride Channels and their Modulation by Neurotransmitters and Drugs.
In: Advances in Biochemical Psychopharmacology, Vol. 45, 1988 (Eds. Biggio G. and Costa E.), Raven Press, New York.
GABA and Benzodiazepine Receptor Subtypes.
In: Advances in Biochemical Psychopharmacology, Vol. 46, 1990 (Eds. Biggio G. and Costa E.), Raven Press, New York.
GABAergic synaptic transmission: Molecular, Pharmacological, and Clinical Aspects.
In: Advances in Biochemical Psychopharmacology, Vol. 47, 1992 (Eds. Biggio G., Concas A. and Costa E.), Raven Press, New York.
GABAA Receptors and Anxiety: From Neurobiology to Treatment
In: Advances in Biochemical Psychopharmacology, Vol. 48, 1995 (Eds. Biggio G., Sanna E., Serra M., and Costa E.), Raven Press, New York. SYMPOSIA IN NEUROSCIENCE SERIES
Receptors as Supramolecular Entities.
In: Advances in the Biosciences. Eds. Biggio G., Costa E., Gessa G.L. and Spano P.F. Symposia in Neuroscience, Vol. 1 (Series Editors: Biggio G. and Costa E.) Vol. 44, 1983, Pergamon Press (Cambridge).
Neuromodulation and Brain Function.
In: Advances in the Biosciences. Eds. Biggio G., Spano P.F., Toffano G. and Gessa G.L., Symposia in Neuroscience, Vol. 2 (Series Editors: Biggio G.and Costa E.), Vol. 48, 1984, Pergamon Press (Cambridge).
Modulation of Central and Peripheral Transmitter Function.
In: Symposia in Neuroscience. Eds. Biggio G., Spano P.F., Toffano G. and Gessa G.L., Vol. 3, 1986, Springer-Verlag (Berlino).
Central Actions of ACTH and Related Peptides.
In: Symposia in Neuroscience. Eds. De Wied D. and Ferrari W., Vol. 4, 1986, Springer-Verlag (Berlino).
Central and Peripheral Dopamine Receptors: Biochemistry and Pharmacology.
In: Symposia in Neuroscience. Eds. Spano P.F., Biggio G., Toffano G. and Gessa G.L., Vol. 5, 1988, Springer-Verlag (Berlino).
Voltage?Sensitive Ion Channels: Modulation by Neurotransmitters and Drugs.
In: Symposia in Neuroscience. Eds. Biggio G., Spano P.F., Toffano G. and Gessa G.L., Vol. 6, 1988, Springer-Verlag (Berlino).
Neuronal Plasticity and Trophic Factors.
In: Symposia in Neuroscience. Eds. Biggio G., Spano P.F., Toffano G., Stanley H. Appel and Gessa G.L., Vol. 7, 1988, Springer-Verlag (Berlino).
Dopamine and Mental Depression.
In: Advances in the Biosciences. Eds. Gessa G.L. and Serra G. Symposia in Neuroscience, Vol. 8 (Series Editors: Biggio G. and Costa E.)- Vol. 77, 1990, Pergamon Press (Cambridge).
Excitatory Amino Acids and Brain Ischemia?Pharmacological and Clinical Aspects.
In: Advances in the Biosciences. Eds. Biggio G., Spano P.F., Toffano G. and Gessa G.L. Symposia in Neuroscience, Vol. 9 Series Editors: Biggio G. and Costa E. - Vol. 78, 1990, Pergamon Press (Cambridge).
LE BENZODIAZEPINE, dalle molecole alla pratica clinica
Ed. Biggio G., 2000 Springer-Verlag Italia, Milano INTERNATIONAL REVIEW OF NEUROBIOLOGY
Neurosteroids and Brain Function
Eds. Biggio G. and Purdy R.H.
In: International Review of Neurobiology, Vol. 46 (Series Editors: Bradley R.J., Harris R.A. and Jenner P.), 2001, Academic Press.
COLLABORATORI:
Dott.ssa Mascia Maria Paola (Ricercatore CNR)
CINQUE LAVORI PIÙ SIGNIFICATIVI PUBBLICATI NEGLI ULTIMI 5 ANNI
Mascia M.P., Trudell J.R., Harris R.A.
Specific Binding Sites for Alcohols and Anesthetics in Ligand-Gated Ion Channels.
Proc.Natl.Acad.Sci. 97: 9305-9310, 2000.
Mascia M.P., Gong D.H., Eger E.I. 2nd, Harris R.A.
The anesthetic potency of propanol and butanol versus propanethiol and butanethiol in alpha1 wild type and alpha1(S267Q) glycine receptors.
Anesth Analg. 91:1289-1293, 2000.
Mascia M.P., Maija R., Borghese C.M., Lobo I.A., Hara K., Yamakura T., Gong D.H., Beckstead M.J.
Does acetaldehyde mediate ethanol action in the central nervous system?
Alcohol Clin. Exp. Res. 25: 1570-1575, 2001.
Mascia M.P., Biggio F., Mancuso L., Cabras S., Cocco P.L., Gorini G., Manca A., Marra C., Purdy R.H., Follesa P., Biggio G.
Changes in GABAA receptor gene expression induced by withdrawal of, but not by long-term exposure to, ganaxolone in cultured rat cerebelar granule cells.
J. Pharmacol. Exp. Ther. 303: 1014-1020, 2002.
Follesa P, Mancuso L, Biggio F, Mostallino MC, Manca A, Mascia MP, Busonero F, Talani G, Sanna E, Biggio G.
Gamma-hydroxybutyric acid and diazepam antagonize a rapid increase in GABA(A) receptors alpha(4) subunit mRNA abundance induced by ethanol withdrawal in cerebellar granule cells.
Mol Pharmacol. 2003 Apr;63(4):896-907. Dott.ssa Mostallino Maria Cristina (Ricercatore CNR)
CINQUE LAVORI PIÙ SIGNIFICATIVI PUBBLICATI NEGLI ULTIMI 5 ANNI
Follesa P, Porcu P, Sogliano C, Cinus M, Biggio F, Mancuso L, Mostallino MC, Paoletti AM, Purdy RH, Biggio G, Concas A.
Changes in GABAA receptor gamma 2 subunit gene expression induced by long-term administration of oral contraceptives in rats.
Neuropharmacology. 2002 Mar;42(3):325-36. Follesa P, Mancuso L, Biggio F, Mostallino MC, Manca A, Mascia MP, Busonero F, Talani G, Sanna E, Biggio G.
Gamma-hydroxybutyric acid and diazepam antagonize a rapid increase in GABA(A) receptors alpha(4) subunit mRNA abundance induced by ethanol withdrawal in cerebellar granule cells.
Mol Pharmacol. 2003 Apr;63(4):896-907. Sanna E, Mostallino MC, Busonero F, Talani G, Tranquilli S, Mameli M, Spiga S, Follesa P, Biggio G.
Changes in GABA(A) receptor gene expression associated with selective alterations in receptor function and pharmacology after ethanol withdrawal.
J Neurosci. 2003 Dec 17;23(37):11711-24. Biggio G, Dazzi L, Biggio F, Mancuso L, Talani G, Busonero F, Mostallino MC, Sanna E, Follesa P.
Molecular mechanisms of tolerance to and withdrawal of GABA(A) receptor modulators.
Eur Neuropsychopharmacol. 2003 Dec;13(6):411-23. Mostallino MC, Mascia MP, Pisu MG, Busonero F, Talani G, Biggio G.
Inhibition by miltirone of up-regulation of GABAA receptor alpha4 subunit mRNA by ethanol withdrawal in hippocampal neurons.
Eur J Pharmacol. 2004 Jun 28;494(2-3):83-90. Sig.ra Maciocco Elisabetta (Tecnico CNR) CINQUE LAVORI PIÙ SIGNIFICATIVI PUBBLICATI NEGLI ULTIMI 5 ANNI
Follesa P, Cagetti E, Mancuso L, Biggio F, Manca A, Maciocco E, Massa F, Desole MS, Carta M, Busonero F, Sanna E, Biggio G.
Increase in expression of the GABA(A) receptor alpha(4) subunit gene induced by withdrawal of, but not by long-term treatment with, benzodiazepine full or partial agonists.
Brain Res Mol Brain Res. 2001 Aug 15;92(1-2):138-48.
Barbaccia ML, Affricano D, Purdy RH, Maciocco E, Spiga F, Biggio G.
Clozapine, but not haloperidol, increases brain concentrations of neuroactive steroids in the rat.
Neuropsychopharmacology. 2001 Oct;25(4):489-97.
Sanna E, Busonero F, Talani G, Carta M, Massa F, Peis M, Maciocco E, Biggio G.
Comparison of the effects of zaleplon, zolpidem, and triazolam at various GABA(A) receptor subtypes.
Eur J Pharmacol. 2002 Sep 13;451(2):103-10.
Campagna F., Palluotto F., Mascia M.P., Maciocco E., Marra C., Carotti A., Carrieri A.
Synthesis and biological evaluation of pyridazino[4,3-b]indoles and benzodiazepine receptors.
Il Farmaco Vol. 58 pp 129-140, 2003.
Campagna F, Palluotto F, Carotti A, Maciocco E.
Synthesis, central and peripheral benzodiazepine receptor affinity of pyrazole and pyrazole-containing polycyclic derivatives.
Farmaco. 2004 Nov;59(11):849-56.
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