Università degli Studi di Cagliari - Dipartimento di Biologia Sperimentale

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Collaborazioni Internazionali dal 1998 | Stampa |
Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, Bethesda, MD 20892-4495 - USA

Ghiani C.A., Eisen A.M., Yuan X., DePinho R.A., McBain CJ. and Gallo V.
Neurotransmitter receptor activation triggers p27kip 1 and p21CIP1 accumulation and G1 cell cycle arrest in oligodendrocyteprogenitors.
Development, 126 (5): 1077-1090, 1999.

Ghiani C.A., Yuan X., Eisen A.M., Knutson P.L., DePinho R.A., McBain CJ. and Gallo V.
Voltage-activated K+ channels and membrane depolarization regulate accumulation of the cyclin-dependent kinase inhibitors p27kip1 and p21CIP1 in glial progenitor cells.
J. Neurosc. 19(13): 5380-5392, 1999.

Dept. Of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97201, USA 

Gupta M., Hogema BM., Grompe M., Bottiglieri T., Concas A., Biggio G., Sogliano C., Rigamonti A., Pearl PL., Snead OC, Jakobs C and Gibson KM
Murine succinate semialdehyde dehydrogenase (SSADH) deficiency (Gamma-Hydroxybutyric Aciduria), a model of human SSADH deficiency associated with tonic-clonic convulsions and elevated GABA
Annals of Neurology 54: 81-90, 2003.

University of Illinois at Chicago School of Medicine, Illinois Psychiatric Institute, 1601 W Taylor Stv. - Chicago, IL 60612 - USA

Pesold C., Impagnatiello P., Pisu M.G., Uzunov D.P., Costa E., Guidotti A. and Caruncho H.J.
Reelin is preferentially expressed in neurons synthesizing g-aminobutyric acid in cortex and hippocampus of adult rats.
Proc. Natl. Acad. Sci. USA 95: 3221-3226, 1998.

Pesold C., Pisu M.G., Impagnatiello F., Uzunov D.P. and Caruncho H.J.
Simultaneous detection of glutamic acid decarboxylase and reelin mRNA in adult rat neuron using in situ hybridization and immunofluorescence.
Brain Res. Prot. 3: 155-160, 1998.

Impagnatiello F., Guidotti A.R., Pesold C., Dwivedi Y., Caruncho H., Pisu M.G., Uzunov D.P., Smalheiser N.R., Davis J.M., Pandey G.N., Pappas G.D., Tueting P., Sharma R.P. and Costa E.
A decrease of reelin expression as a putative vulnerability factor in schizophrenia.
Proc. Nati. Acad. Sci. USA., 95: 15718-15723, 1998.

Department of Neurobiology,  University of Texas at Austin Institute for Cellular and Molecular Biology, 2500 Speedway  MBB 1.124 - Austin, TX  78 712   U.S.A.

Ye Q., Koltchine V.V., Mihic S.J., Mascia M.P., Wick M.J., Finn S.E., Harrison N.L. and Harris R.A.
Enhancement of glycine receptor function by ethanol is inversely correlated with molecular volume at position a 267.
J. Biochem. Chem. 273: 3314-3319, 1998.

Mascia M.P., Wick M.J., Martinez L. and Harris R.A.
Enhancement of glycine receptor function by ethanol: role of phosphorylation.
British J. Pharmacol. 125: 263-270, 1998

Wick M.J., Mihic J., Ueno S., Mascia M.P., Trudell J.R., Brozowski S.J., Ye Q., Harrison N.L. and Harris A.
Mutations of g-amino butyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor?
Proc. Nati. Acad. Sci. USA., 95: 6504-6509, 1998.

Mascia M.P., Trudell J.R and Harris R.A.
Specific Binding Sites for Alcohols and Anesthetics in Ligand-Gated Ion Channels.
Proc.Natl.Acad.Sci. 97 :9305-9310, 2000.

Wick M.J., Radcliffe R.A., Bowers B.J., Mascia M.P., Luscher B., Harris R.A. and Wehner JM
. Behavioural changes produced by transgenic overexpression of gamma2L and gamma2S subunits of the GABAA receptor.
Eur J Neurosci. 12 : 2634-2638, 2000.

Mascia M.P.,Gong D.H., Eger E.I. 2nd and Harris R.A.
The anesthetic potency of propanol and butanol versus propanethiol and butanethiol in alpha1 wild type and alpha1(S267Q) glycine receptors.
Anesth Analg. 91:1289-1293, 2000.

Zhang Y., Trudell J.R.,Mascia M.P., Laster M.J., Gong D.H., Harris R.A. and Eger E.I. 2nd.
The anesthetic potencies of alkanethiols for rats: relevance to theories of narcosis.
Anesth Analg. 91:1294-1299, 2000.

Ueno S., Harris R.A., Messing R.O., Sanchez-Perez A.M., Hodge C.W., McMahon T., Wang D.,  Mehmert K.K., Kelley S.P., Haywood A., Olive M.F., Buck K.J., Hood H.M., Blednov Y., Findlay G. and Mascia M.P.
. Alcohol actions on GABA(A) receptors: from protein structure to mouse behavior.
Alcohol Clin Exp Res. 25:76S-81S, 2001.

Findlay G.S., Wick M.J.,Mascia M.P., Wallace D.,  Miller G.W., Harris R.A. and Blednov Y.A.
Transgenic expression of a mutant glycine receptor decreases alcohol sensitivity of mice.
J Pharmacol Exp Ther. 300:526-534, 2002.

University of Dundee, Ninewells Hospital and Medical School Dundee DD1 9SY, Scotland - U.K. Ricerca in corso:
Valutazione dell'attività di derivati del propofol privi di effetto anestetico sui recettori GABAA espressi in oociti.

Belelli D., Pau D., Cabras G., Peters J.A. and Lambert J.J.
A single amino acid confers barbiturate sensitivity upon the GABA r1 receptor.
British J. Pharmacol., 126: 1455-1458, 1999.

Georgetown University, Department of Cell Biology, 3900 Reservoir Road, Washing­ton, DC 20007 - USA

Colangelo A.M., Follesa P., and Mocchetti I.
Differental induction of nerve growth factor and basic fibroblast growth fact mRNA in neonatal and aged rat brain.
Mol. Brain Res. 53: 218-225, 1998.

Follesa P., Wrathall J.R. and Mocchetti I.
2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)-quinoxaline (NBQX) increases fibroblast growth factor mRNA levels after confusive spinal cord injury.
Brain Res. 782: 306-309,1998.

Brandoli C., Sanna A., De Bernardi M.A., Follesa P., Brooker G. and Mocchetti I.
Brain-derived neurotrophic factor and basic fibroblast growth factor downregulate NMDA receptor function in cerebellar granule cells.
J. Neurosci., 18(19): 7953-7961,1998.

Mallei A., Shi B. and Mocchetti I.
Antidepressant treatments induce the expression of basic fibrobalst growth factor in cortical and hippocampal neurons.
Mol. Pharmacol. 61: 1017-1024, 2002.

Department of Pharmacology. UCLA Sch Med, Los Ange­les, CA 90024 - USA Ricerca in corso:
Effetto di derivati del propofol privi di attività anestetica in topi transgenici mancanti della subunità b3 recettore GABAA.

Cagetti E., Liang J., Spigelman I. and Olsen R.W.
Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABAA receptor.
Mol. Pharmacol. 63: 53-64, 2003.

Spigelman I., Li Z., Liang J., Cagetti E., Samzadeh S., Mihalek R.M., Homanics G.E. and Olsen R.W.
Reduced inhibiton and sensitivity to neurosteroids in hippocampus of mice lacking the GABAA receptor {delta} subunit.
J. Neurophysiol. 2003.

Department of Psychiatry, Veterans Affairs Medical Cen­ter, University of California 3350 La Jolla, Village Drive - San Diego, California 92161 - USA

Concas A., Mostallino M.C., Porcu P., Follesa P., Barbaccia M.L., Trabucchi M., Purdy R.H., Grisenti P. and Biggio G.
Role of brain allopregnanolone in the plasticity of g-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery.
Proc. Natl. Acad. Sci. 95: 13284-13289, 1998.

Serra M., Madau P., Chessa M.F., Caddeo M., Sanna E., Trapani G., Franco M., Liso G., Purdy R.H., Barbaccia M.L. and Biggio G.
2-phenyl-imidazo[1,2-a]pyridine derivatives as ligands for peripheral benzodiazepine receptors: stimulation of neurosteroid synthesis and anticonflict action in rats.
British J. Pharmacol. 127: 177-187, 1999.

Concas A., Follesa P., Barbaccia M.L., Purdy R.H. and Biggio G.
Physiological modulation of GABAA receptor plasticity by progesterone metabolites.
Eur. J. Pharmacol. 375: 225-235, 1999.

Concas A., Porcu P., Sogliano C., Serra M., Purdy R.H. and Biggio G.
Caffeine-induced increases in the brain and plasma concentrations of neuroactive steroids in the rat.
Pharmacol. Biochem and Behav. 66: 39-45, 2000.

Serra M., Pisu M.G., Littera M., Papi G., Sanna E., Tuveri F., Usala L., Purdy R.H. and Biggio G.
Social isolation-induced decreases in both the abundance of neuroactive steroids and GABAA receptor function in rat brain.
J. Neurochem. 75: 732-740, 2000.

Biggio G., Barbaccia M.L., Follesa P., Serra M., Purdy R.H. and Concas A.
Neurosteroids and GABAA receptor plasticity.
In: GABA in the nervous system. The view at fifty years" (Eds. Olsen R.W. and Martin D.L.). Lippincott, pp. 207-232, 2000.

Serra M., Littera M., Pisu M.G., Muggironi M., Purdy R.H. and Biggio G.
Steroidogenesis in rat brain induced by short- and long-term administration of carbamazepine.
Neuropharmacol.  39: 2448-2456, 2000.

Biggio G., Follesa P., Sanna E., Purdy R.H. and Concas A.
GABAA-receptor plasticity during long-term exposure to an withdrawal from progesterone.
In: Neurosteroids and Brain Function (Eds. Biggio G. and Purdy R.H.),
International Review of Neurobiology, Academic Press, Vol. 46, pp. 207-241,  2001.

Barbaccia M.L., Serra M., Purdy R.H. and  Biggio G.
Stress and neuroactive steroids.
In: Neurosteroids and Brain Function (Eds. Biggio G. and Purdy R.H.),
International Review of Neurobiology, Academic Press, Vol. 46, pp. 243-2  272,  2001.

Barbaccia M.L., Affricano D., Purdy R.H.,
Maciocco E., Spiga F. and Biggio G.

Clozapine, but not haloperidol, increases brain concentrations of neuroactive steroids in the rat.
Neuropsychopharmacol.,25: 489-497, 2001.

Serra M., Pisu M.G., Muggironi M., Parodo V., Papi G., Sari R., Dazzi L., Spiga F., Purdy R.H. and Biggio G.
Opposite effects of short- versus long-term administration of fluoxetine on the concentrations of neuroactive steroids in rat plasma and brain.
Psychopharmacol.,158: 48-54, 2001.

Follesa P. , Concas A., Porcu P., Sanna E., Serra M., Mostallino M.C., Purdy R.H. and Biggio G.
Role of allopregnanolone in regulation of GABAA receptor plasticity during long-term exposure to and withdrawal from progesterone.
Brain Res., 37: 81-90, 2001

Dazzi L., Ladu S., Spiga F., Vacca G., Rivano A., Pira L. and Purdy R.H.
Chronic treatment with imipramine or mirtazapine antagonizes stress- and FG7142- induced increase in cortical norepinephrine output in freely moving rats.
Synapse, 43: 70-77, 2002.

Follesa P., Porcu P., Sogliano C., Cinus M., Biggio F., Mancuso l., Mostallino M.C., Paoletti A.M., Purdy R.H., Biggio G. and Concas A.
Changes in GABAA receptor γ2 subunit gene expression induced by long-term administration of oral contraceptives in rats.
Neuropharmacol., 42: 325-336, 2002

Serra M., Pisu M.G., Dazzi L., Purdy R.H. and Biggio G.
Prevention of the stress-induced increase in the concentration of neuroactive steroids in rat brain by long-term administration of mirtazapine but not of fluoxetine.
J. Psychopharmacol., 16 (2): 133-138, 2002.

Mascia M.P., Biggio F., Mancuso L., Cabras S., Cocco P.L., Gorini G., Manca A., Marra C., Purdy R.H., Follesa P. and Biggio G.
Changes in GABAA receptor gene expression induced by withdrawal of, but not by long-term exposure to, ganaxolone in cultured rat cerebelar granule cells.
J. Pharmacol. Exp. Ther. 303: 1014-1020, 2002

Dazzi L., Serra M., Seu E., Cerchi G., Pisu M.G., Purdy R.H. and Biggio G.
Progesterone enhances ethanol-induced modulation of mesocortical dopamine neurons: antagonism by finasteride.
J. Neurochem. 83: 1103-1109, 2002.

Porcu P., Sogliano C., Cinus M., Purdy R.H., Biggio G. and Concas A.
Nicotine-induced changes in cerebrocortical neuroactive steroids and plasma corticosterone concentrations in the rat. Phamacol. Biochem. Behav.74: 683-690, 2003.

Serra M., Pisu M.G., Floris I., Cara V., Purdy R.H. and Biggio G.
Social isolation-induced increase in the sensitivity of rats to the steroidogenic effect of ethanol.
J. Neurochem. 85: 257-263, 2003.

Porcu P, Sogliano C, Ibba C, Piredda M, Tocco S, Marra C, Purdy RH, Biggio G, Concas A.
Failure of gamma-hydroxybutyric acid both to increase neuroactive steroid concentrations in adrenalectomized-orchiectomized rats and to induce tolerance to its steroidogenic effect in intact animals.
Brain Res. 2004 Jun 25;1012(1-2):160-8.

UCLA, Sch Med., Los Angeles, CA 90024 - USA Ricerca in corso:
Valutazione dei livelli plasmatici di neurosteroidi in pazienti con sin­drome premestruale.

Rasgon N., Serra M., Biggio G., Pisu M.G., Fairbanks L., Tanavoli S. and Rapkin A.
Neuroactive steroid-serotonergic interaction: responses to an intravenous L-tryptophan challenge in women with premenstrual syndrome.
Eur. J. Endocrinol.145: 25-33, 2001.  

Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510 - USA

Jentsch J.D., Dazzi L., Chhatwal J.P., Verrico C.D. and Roth R.H.
Reduced prefrontal cortical dopamine, but not acetylcholine, release in vivo after repeated, intermittent phencyclidine administration in rats.
Neuroscience Letters 258: 1-4, 1988.

Verrico C.D., Jentsch J.D., Dazzi L. and Roth R.H.
Systemic, but not local, administration of cannabinoid CB1 receptor agonists modulate prefrontal cortical acetylcholine efflux in the rat.
Synapse 48: 178-183, 2003.  

Merck Sharp & Dohme Research Laboratories Neuroscience Research Centre - Terlings Park Eastwick Road, Harlow, Essex CM20 2QR - U.K.

Thompson S.A., Bonnert T.P., Cagetti E., Whiting P.J. and Wafford K.A.
Overexpression of the GABA(A) receptor epsilon subunit results in insensitivity to anaesthetics.
Neuropharmacology 43: 662-668, 2002.


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